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On February 11, 2021, a research article entitled "Mediator structure and conformation change" was published in Molecular Cell. This report, based on a joint effort of the Lab of Structure Biochemistry at Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and collaborators from Stanford describes, for the first time, the cryo-EM structure of the entire Mediator at a near...

On December 18th, SIAIS held the fourth Meeting of the 1st SIAIS Academic Committee in the ShanghaiTech Conference Center. Thirteen SIAIS Academic Committee members, composed of distinguished experts in the field of biomedical research, and thirty representatives of SIAIS faculty attended the meeting.  The meeting was hosted by Rao Zihe, Distinguished Adjunct Professor of SIAIS and Membe...

On August 26th, 2020, a team led by SIAIS Distinguished Adjunct Professor Lin Haifan published new findings in PNAS in an article entitled “PIWIL1 Promotes Gastric Cancer via a piRNA-Independent Mechanism”. These findings reveal a new function and action mechanism of PIWI proteins in oncogenesis, guiding the identification of PIWI inhibitors to cure cancer.   Precision m...

On November 3rd, 2020, a team led by SIAIS Distinguished Adjunct Professor Fan Guoping and Research Associate Professor Zhu Xianmin published new findings in the Springer Nature Group Journal Oncogene with the title of “Single-cell RNA sequencing reveals the heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations”. This work is ...

On October 30, 2020, a research article entitled “Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC” was published in Science Advances by a joint research team led by Prof. Rao Zihe, a Distinguished Adjunct Professor at Shanghai Institute for Advanced Immunochemical Studies (SIAIS). This work reported four high-resolution cryo-electron microscopy structure...

On the afternoon of November 2nd, the Portrait Unveiling Ceremony for Richard A. Lerner, Distinguished Adjunct Professor and the Founding Director of SIAIS, was held in the Y Building. Jiang Ge, Vice President of ShanghaiTech and Executive Director of SIAIS welcomed distinguished guests: Roger Kornberg, the 2006 Nobel Prize Laureate in Chemistry and Professor of Stanford University; Michael Levitt...

Professor Katsuhiko Mikoshiba from the School of Life Science and Technology (SLST) and SIAIS, in collaboration with Professor Makoto Tsuda’s group in Kyushu University, have published research findings in Nature Neuroscience describing a novel type of astrocyte involved in pain regulation: Noradrenergic stimulation aggravates pain through the novel astrocytes, opposite to the classical...

Since developed in 1980s by Prof. Richard Lerner and Prof. Gregory Winter, 2018 Nobel Laureate in Chemistry, combinatorial antibody library technology has been applied in biomedical development and basic science research, etc. Prof. Richard Lerner extended the application of combinatorial antibody to many fields, such as enzyme catalysis, receptor activation and cell fate regulators...

 Professor Katsuhiko Mikoshiba from SIAIS, with the French Professor Valentin N?gerl’s group unraveled the morphological mystery of astrocytes.  Misa Arizono, a former PhD student in Mikoshiba’s lab is the first author of this report in Nature Communications 2020.Astrocytes, which are the most numerous...

At 11 PM (Beijing Time) on 8th July, a new research finding was reported by the joint research team led by Prof. Rao Zihe, Distinguished Adjunct Professor at Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and Professor Luke Guddat (Visiting Professor at SIAIS and Professor at University of Queensland). The related research article entitled “Structures of fungal...

Recently, Angewandte Chemie International Edition published a collaborative study led by Professors Richard A. Lerner and Yang Guang from Shanghai Institute for Advanced Immunochemical Studies (SIAIS) of ShanghaiTech University, entitled “A Chemistry for Incorporation of Selenium into DNA-Encoded Libraries”. This paper has been highlighted as Very Important Paper (Top 5%...

The 3C protease has long been the focus of enterovirus antiviral development. Nevertheless, although anti-enterovirus drugs have a potentially enormous global market, the nucleophilic active site of 3C has frustrated previous drug discovery efforts. Recently, a team of scientists led by Dr. Yang Bei and Dr. Ian A. Wilson from the Laboratory of Antibody Structure at the Shanghai Institute for ...

On May 8, 2020, the Founding Ceremony was held for the Anti-Tuberculosis (TB) Structure Center (A-TB Center) of Shanghai Institute for Advanced Immunochemical Studies (SIAIS) at ShanghaiTech University. The ceremony was followed by the First Academic Symposium of the A-TB Center at SIAIS. President Jiang Mianheng and Professor Rao Zihe at SIAIS, Member of the Chinese Academy of Sciences (CAS), joi...

A research group led by Prof. Katsuhiko Mikoshiba from Shanghai Institute for Advanced Immunochemical Studies (SIAIS) at ShanghaiTech University proposes a novel and simple method for creating a stable cytoplasmic antibody, termed STAND, which can be correctly folded and stably expressed in the cytoplasm of the cells. Without the need for complicated amino acid substitutions, it successfully conve...