• SIAIS Researchers Unveil Structures of Cell Wall Arabinosyltransferases with the First-Line Anti-tuberculosis Drug Ethambutol
    At 2:00 AM (Beijing Time) on 24th April, a research article titled “Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol” as reported by the joint research team led by Prof. Rao Zihe, Distinguished Adjunct Professor at Shanghai Institute for Advanced Immunochemical Studies (SIAIS), was published via First Release in Science. This work, for...
    2020-04-24
  • SIAIS Researchers Discover First Anti-CRISPR Peptides Providing Insights into Developing Next-Generation CRISPR Inhibitors for Precision Genome Editing
    Recently, Research Associate Professors Liu Jia, from Lab of Macromolecular Drug Delivery and Ma Peixiang,from Lab of Phenotypic Screening at SIAIS, ShanghaiTech University, reported the first anti-CRISPR peptides. These peptides are derived from the periplasmic domain of the major coat protein G8P (G8PPD) of inoviridae bacteriophages and can allosterically inactivate...
    2020-04-16
  • SIAIS Researchers Determine Structure of RNA-Dependent RNA Polymerase - a Major Antiviral Drug Target of COVID-19 Virus
    On April 10, 2020, a joint research team led by Rao Zihe, Distinguished Adjunct Professor at SIAIS (Shanghai Institute for Advanced Immunochemical Studies), ShanghaiTech University, Wang Quan, Assistant Professor at School of Life Science and Technology (SLST) and SIAIS, ShanghaiTech University and Lou Zhiyong, Research Professor at Tsinghua University, published their research findings in Sc...
    2020-04-10
  • SIAIS Professors Rao Zihe and Yang Haitao Determine Structure of Mpro From COVID-19 Virus and Discover Its Inhibitors
    Recently, professors Rao Zihe and Yang Haitao at SIAIS (Shanghai Institute for Advanced Immunochemical Studies) of ShanghaiTech University, together with their collaborators, have determined the high-resolution crystal structure of main protease (Mpro) from COVID-19 virus and identified drugs that may have promise against COVID-19. Invited by ...
    2020-04-10
  • SIAIS Holds COVID-19 Symposium
    Researchers from SIAIS of ShanghaiTech have been engaged in the race against COVID-19 since the epidemic broke out in January 2020. To accelerate the research work of specific drugs, a symposium on COVID-19 research work was held at SIAIS on March 24. The symposium was hosted by Dr. Jiang Ge, the Executive Director of SIAIS, Vice Provost of ShanghaiTech. Attendees included Dr. Yin Jie, Vice P...
    2020-04-04
  • Structure of RNA-Dependent RNA Polymerase - a Major Antiviral Drug Target of 2019-nCoV
    Recently, a joint research team led by Rao Zihe, Distinguished Adjunct Professor at SIAIS (Shanghai Institute for Advanced Immunochemical Studies), ShanghaiTech University, Wang Quan, Assistant Professor at School of Life Science and Technology (SLST) and SIAIS, ShanghaiTech University and Lou Zhiyong, Associate Professor at Tsinghua University, reported a 2.9 ? cryo-EM structure of the RNA-d...
    2020-03-20
  • SIAIS Professors Rao Zihe and Yang Haitao’s Research Team Determine the Crystal Structure of SARS-CoV-2 3CL Hydrolase
    On January 26th, professors Rao Zihe and Yang Haitao’s research team at SIAIS (Shanghai Institute for Advanced Immunochemical Studies) of ShanghaiTech University determined the high-resolution crystal structure of SARS-CoV-2 3CL hydrolase (Mpro), the only public-domain 3D structure from SARS-CoV-2 currently. The structure data can be downloaded at PDB (Protein Data B...
    2020-02-15
  • The Joint Research Team of ShanghaiTech and Shanghai Institute of Materia Medica Discovers a Series of Drugs with Potential for COVID-19 Treatment
    When the epidemic of COVID-19 broke out, a joint research team was set up quickly, to enable research work on understanding the virusand accelerate the drug discovery. Led by professors Jiang Hualiang and Rao Zihe, the team is formed by over 20 research groups from SIAIS (Shanghai Institute for Advanced Immunochemical Studies) of ShanghaiTech and Shanghai Institute of...
    2020-02-15
  • Youth Shu Lan Medicine Award Honors Dr. Yang Haitao
    Dr. Yang Haitao, Shanghai Institute of Advanced Immunochemical Institute (SIAIS) Principal Investigator, recently was awarded the 2019 Youth Shu Lan Medicine Award, marking the first time a ShanghaiTech faculty member won this  prize.Youth Shu Lan Medicine Award Winners and the PresentersThe Shu Lan Medicine Awards, first awarded in 2014, recognize distinguished scientists and scholars. Youth...
    2019-12-31
  • Research Proposes New Concepts in IP3 Receptor Plasticity
    Annual Review of Physiology
    In November, SIAIS Professor Katsuhiko Mikoshiba and Research Associate Professor Kozo Hamada of Cell Calcium Signaling laboratory published a review paper entitled ‘IP3 Receptor Plasticity Underlying Diverse Functions’ in Annual Review of Physiology. The paper reviews recent progress on the IP3 receptor structure and function, and the authors propose a new concept of how protein plast...
    2019-12-06
  • New Research Results Unveil Structure of African Swine Fever Virus
    Science
    SIAIS Principal Investigator Dr. Rao Zihe and his team recently unveiled the 3-dimensional structure of the African swine fever (ASF) virus, a giant and complex virus which causes a contagious and lethal swine disease all over the world. The study, entitled ‘Architecture of African swine fever virus and implications for viral assembly,’ was published in Science on Oct 17th.  Since...
    2019-11-02
  • Sino-German Symposium Highlights Translational Oncology
    The Sino-German Symposium Shanghai 2019 was held successfully from September 17th to 21st 2019 at ShanghaiTech University. The symposium was jointly organized by ShanghaiTech University and German Cancer Research Center (DKFZ), with the support from Das Chinesisch-Deutsche Zentrum für Wissenschaftsf?rderung (CDZ, the Sino-German Center for Research Promotion). Under the theme of ‘Frontiers in tr...
    2019-09-26
  • SIAIS Welcomes Leiden University Delegation
    On September 17t, a delegation from Leiden University in Netherland visited Shanghai Institute for Advanced Immunochemical Studies (SIAIS). The delegation, led by Professor Peter ten Dijke and Professor. Jacques Neefjes, met with the Executive Director of SIAIS, Jiang Ge at the Y Building. Associate Professor David Baker and Assistant Professor Baoxu Pang from Leiden University Medical Center also...
    2019-09-25
  • SIAIS Hosts PROTAC Drug Discovery and Development Symposium
    The first Symposium on Frontier in PROTAC Drug Discovery and Development was held on May 16th by the Shanghai Institute for Advanced Immunochemical Studies (SIAIS) at the Conference Center of ShanghaiTech University. This symposium received wide attention and enthusiastic response from the more than 600 attendees from enterprises and academia in China and abroad. Notably, more than half of the att...
    2019-06-06