• 6th Frontier of Genome Engineering Forum Held at ShanghaiTech
    On October 19th to 20th, SLST held its sixth annual Frontier of Genome Engineering (FoGE2018). Vice President and Provost Yin Jie delivered opening remarks, highlighting the remarkable progress that ShanghaiTech University has achieved. The conference was officially opened by SLST Vice Dean Professor Liu Jilong, who focused on the SLST’s achievements in the last few years. Nearly 400 researchers ...
    2018-11-07
  • Scientists Develop Novel 4D Genome Imaging Technique
    Nature Methods
    CRISPR-Sirius, a sensitive and bright imaging system, has been developed by research groups led by Dr. Ma Hanhui at ShanghaiTech University and Dr. Thoru Pederson at the University of Massachusetts Medical School. Their study was recently published in Nature Methods, a prestigious scientific journal.CRISPR-Sirius makes it possible to detect low-copy repeats distributed in the intergenic and genic ...
    2018-10-31
  • Series of Novel Base Editors Developed
    Nature Biotechnology
    A team of scientists led by Dr. Jia Chen and Dr. Xingxu Huang from ShanghaiTech’s School of Life Science and Technology and Dr. Li Yang from the CAS-MPG Partner Institute for Computational Biology at the Chinese Academy of Sciences, have developed a series of novel base editors (BEs) using a spectrum of cytidine deaminases from different species, including human APOBEC3A (hA3A). Their work, ...
    2018-08-21
  • Novel Proximity Tagging System Developed
    Nature Methods
    Cell and cellular organelles communication are often controlled by the membrane protein interaction. Despite the many existing methods to detect protein-protein interactions (PPIs), there are still challenges in detecting membrane PPIs. Transient and weak PPIs are mostly associated with membrane receptor-mediated signaling pathways. Mass spectrometry-based membrane protein interaction studies have...
    2018-08-15
  • New DNA Replication Pathway Revealed
    Nature Communications
    A recent international research collaboration has shed new light on DNA replication. The collaboration, led by Professor Bo Sun from the School of Life Science and Technology at ShanghaiTech University and Professor Michelle D. Wang from the Howard Hughes Medical Institute (HHMI) and Cornell University, revealed a new replication recovery pathway. Their paper, “Helicase Promotes Replication Re-in...
    2018-06-15
  • Immunotherapy Response Predictive Biomarkers Identified
    Oncogene
    The prognosis of late stage cancer patients after traditional cancer treatments such as radiation, surgery and chemotherapy is always poor. Immunotherapy with antibodies targeting immune checkpoints represents a major breakthrough in cancer treatment. Some cases of patients previously consideredincurable are now able to be cured through immunotherapy. However, only a fraction of patients show...
    2018-05-14
  • AAAS Elects SLST Dean as a Member
    Lin Haifan, Founding Dean of School of Life Science and Technology (SLST) of ShanghaiTech, Yale University Professor of Cell Biology and Reproductive Sciences and Director of the Yale Stem Cell Center, was among 213 academics newly elected as members of the American Academy of Arts and Sciences (AAAS), which celebrates excellence in a wide range of disciplines.Professor Lin’s work focuses on the ...
    2018-04-19
  • International Immunology Collaboration Published
    PNAS
    An international effort within the immunology research community resulted in the first genome-wide CRISPR screen focused on the molecular mechanism of T cell function regulation. A group of scientists led by Dr. Haopeng Wang of ShanghaiTech’s School of Life Science and Technology, along with Dr. Arthur Weiss at UCSF and Dr. Lai Wei of the Zhongshan Ophthalmic Center at Sun Yat-sen University...
    2018-04-09
  • Base editing with a Cpf1– cytidine deaminase fusion
    Nature Biotechnology
    A team of scientists led by Dr. Jia Chen and Dr. Xingxu Huang of the School of Life Science and Technology at ShanghaiTech University, along with Dr Li Yang of the CAS-MPG Partner Institute for Computational Biology at the Chinese Academy of Sciences, have developed a series of novel CRISPR/Cpf1 (Cas12a) bases editors. The paper entitled “Base editing with a Cpf1– cytidine deaminase fusion”...
    2018-03-28
  • SLST Researchers' Neuroscience Findings Published
    Nature Neuroscience
    Nature Neuroscience recently published a study demonstrating that the transcription of multiple genes in the brain can be simultaneously activated using CRISPR–dCas9-activator transgenic mice. This work was performed by researchers in Dr. YANG Hui’s lab at the Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Techn...
    2018-01-26
  • ShanghaiTech Scientists Reveal APOBEC's Effect on Gene Editing
    Nature Structural and Molecular Biology
    A team of scientists led by Dr. Jia Chen in the School of Life Science and Technology at ShanghaiTech University, Dr. Li Yang in the CAS-MPG Partner Institute for Computational Biology at the Chinese Academy of Sciences, and Dr. Bin Shen in the State Key Laboratory of Reproductive Medicine in the Department of Histology and Embryology at Nanjing Medical University has revealed that APOBEC3 induces...
    2017-12-13
  • SLST Hosts Genetics and Genomics Conference
    ShanghaiTech’s School of Life Science and Technology (SLST) held the 5th Annual ShanghaiTech BioFrontier Conference -- Frontier of Genetics and Genomics (FoGG2017) on October 20-21st, 2017, in the auditorium of the newly completed L building, the home of SLST.Nearly 300 researchers from leading institutions gathered at the conference to present and discuss cutting-edge progress in a broad sp...
    2017-10-25
  • SLST Lab's Liver Regeneration Finding Published in Hepatology
    Hepatology
    A team led by Assistant Professor Huang Pengyu at ShanghaiTech University’s School of Life Science and Technology, collaborating with Sun Yat-sen Memorial Hospital at Guangzhou, found an important role of IGF-2 in liver regeneration induced by some chronic liver injuries. Their work entitled “Pericentral hepatocytes produce IGF-2 to promote liver regeneration during special injuries” was publis...
    2017-09-07
  • SLST Researchers' Genetic Engineering Findings Published
    Cell Research
    Genome editing is a type of genetic engineering, which utilizes programmable nucleases such as the Cas9 nuclease to achieve desired base insertion, deletion or substitutions in the genome of living organisms. Directed by guide RNA (gRNA), Cas9 nuclease can generate DNA double strand breaks (DSBs) at targeted genomic sites. Subsequent resolving of the generated DSB through non-homologous end joinin...
    2017-08-31